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Only recently, a risk prediction model was developed for this group of patients.

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Follow-up with questionnaire-based assessment eex take place every 26 weeks until death of participant or end of the SMART study, asking participants about possible new cardiovascular events.

Endpoints will be adjudicated by a committee of three experts. The aim is to collect future events.

The main analysis will consist fref Cox proportional hazard analysis. Imaging biomarkers will be added to the existing prediction model to assess their independent discriminatory capacity for future events.

The c-statistic will be used to measure the discrimination of each model. Net reclassification improvement tables will be constructed to evaluate the added value of imaging markers in terms of reclassification.

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